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Updated: Jun 17, 2026
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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
Corneal Transplantation on an Opaque Cornea
Proceedings of the Royal Society of Medicine
|December 9, 2009
Summary
Corneal transplantation restored vision in a patient with severe corneal opacity. This early surgical technique, involving a glass disc, showed promising results for vision restoration in corneal disease.
Area of Science:
- Ophthalmology
- Surgical Innovation
Background:
- Patient presented with bilateral corneal opacity and severely reduced vision (hand movements) at age 22.
- Opacity resulted from interstitial keratitis at age 18.
Purpose of the Study:
- To evaluate the efficacy of corneal transplantation for vision restoration in a patient with severe corneal opacity.
- To document the surgical technique and outcomes of an early corneal graft procedure.
Main Methods:
- Corneal transplantation performed on the left eye using a graft from a donor eye with a perforating injury history.
- Surgical technique included cocaine anesthesia, a glass disc interposition, and shelving cuts for graft margins.
- Graft was slightly smaller than the excised opaque cornea.
Main Results:
- Graft showed good initial union and clarity by day 10.
- Temporary haze and neovascularization occurred in the first week post-operation.
- Vision improved significantly, with the patient counting fingers at 2 ft by 4 months and up to 33 inches by 2 years.
Conclusions:
- Corneal transplantation can be an effective treatment for vision loss due to corneal opacity.
- The described surgical modifications, including the glass disc, may have contributed to successful graft integration and visual recovery.
