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Chromosome assignment of four RAS-related RAB genes
M F Rousseau-Merck1, A Zahraoui, N Touchot
1INSERM U.301, Institut de Génétique Moléculaire, Paris, France.
Human Genetics
|February 1, 1991
Abstract:
The human RAB genes share structural and biochemical properties with the RAS gene superfamily. The encoded RAB proteins show 38 to 75% amino acid identity with the yeast YPT1 and SEC4 gene products. We used four human RAB-cDNAs, RAB3B, RAB4, RAB5 and RAB6, to map the corresponding genes on human chromosomes. These genes were assigned to 1p32-p31, 1q42-q43, 3p24-p22 and 2q14-q21, respectively, by in situ hybridization.