Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population
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S Olschwang1, P Laurent-Puig, A Vassal
1Laboratoire de Génétique Moléculaire des Tumeurs, Institut Curie, Paris, France.
Human Genetics
|February 1, 1991
Abstract:
We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.