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Published on: July 8, 2025
[Postoperative hyponatremia in pediatric patients]
A R Fernández1, M A Ariza, J L Casielles
1Departamento de Anestesiología y Reanimación, Hospital Universitario Virgen Macarena, Sevilla. antonio@gonzalo5292.jazztel.es
Insights
Pediatric fluid replacement using hypotonic solutions may increase the risk of hyponatremic encephalopathy. Further research is needed to determine optimal fluid therapy strategies for children undergoing surgery.
Area of Science:
- Pediatric Medicine
- Nephrology
- Critical Care Medicine
Background:
- For 50 years, pediatric fluid therapy relied on the Holliday-Segar formula with hypotonic solutions.
- Recent concerns highlight postoperative hyponatremia, morbidity, and mortality, questioning current fluid therapy practices.
Observation:
- Three cases of hyponatremic encephalopathy in children after minor surgery are presented.
- Kidney's free water excretion is a key factor, but optimal pediatric fluid therapy remains debated.
Findings:
- Current fluid therapy strategies and volumes are under scrutiny due to hyponatremia risks.
- The debate on perioperative fluid therapy effectiveness and safety continues.
Implications:
- Urgent need for large randomized clinical trials comparing hypotonic and isotonic solutions in pediatric patients.
- Developing evidence-based recommendations to minimize electrolyte disturbances and their complications in pediatric surgical patients.
Abstract:
Fluid replacement therapy for pediatric patients in the past 50 years has meant the infusion of hypotonic solutions in amounts calculated using the Holliday-Segar formula. Recent studies have focused attention on the incidence of postoperative hyponatremia and associated morbidity and mortality rates, generating debate on the advisability of perioperative fluid therapy and calling into question both the effectiveness of this strategy and the quantities used. We report 3 cases of hyponatremic encephalopathy in children following different types of minor surgery. Free water excretion by the kidneys is known to be a conditioning factor in this therapy, yet the ideal way to provide pediatric fluid therapy is still hotly debated. The question cannot be resolved until large randomized clinical trials are carried out to compare the use of hypotonic and isotonic solutions. Some general recommendations can be offered, however, in the interest of lowering the incidence of electrolyte disturbances and diminishing their repercussions.
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