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Related Experiment Video

Updated: Jun 17, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Single gold microshell tailored to sensitive surface enhanced Raman scattering probe.

Lilin Piao1, Sejin Park, Hyang Bong Lee

  • 1Department of Chemistry, Seoul National University, Seoul 151-747, Korea.

Analytical Chemistry
|December 10, 2009
PubMed
Summary

Researchers developed a novel surface-enhanced Raman scattering (SERS)-active platform using gold-coated microspheres. This platform enables rapid, individual molecule fingerprinting on various surfaces, paving the way for advanced molecular detection and decoding applications.

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Area of Science:

  • Nanotechnology
  • Spectroscopy
  • Materials Science

Background:

  • Surface-enhanced Raman scattering (SERS) is a powerful technique for molecular detection.
  • Developing sensitive and versatile SERS-active platforms remains a key challenge.
  • Individual manipulation and analysis of SERS probes are crucial for specific applications.

Purpose of the Study:

  • To create a finely tuned, SERS-active platform using gold-coated polystyrene microspheres.
  • To enable the acquisition of unique SERS spectra from molecules on individual microspheres.
  • To demonstrate the platform's utility for analyzing molecules on diverse metal surfaces.

Main Methods:

  • Fabrication of 2-micrometer polystyrene microspheres with a precisely controlled gold shell.
  • Manipulation of individual microspheres using a micropipette under optical microscopy.
  • Acquisition of SERS spectra from molecular monolayers on platinum and gold surfaces using the microspheres.

Main Results:

  • Achieved strong SERS activity from molecules on the surface of the gold-coated microspheres.
  • Demonstrated individual microsphere manipulation and SERS spectral acquisition.
  • Obtained well-defined SERS spectra with millisecond acquisition times on Pt and Au surfaces.

Conclusions:

  • The proposed gold-coated microspheres serve as effective, individually addressable SERS probes.
  • The platform allows for sensitive detection and fingerprinting of molecular monolayers without special surface preparation.
  • This system holds promise for applications involving SERS-active barcodes and rapid molecular decoding.