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Updated: Jun 17, 2026

Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of
Pietro Speziale1, Giampiero Pietrocola, Simonetta Rindi
1Department of Biochemistry, 27100 Pavia, Italy. pspeziale@unipv.it
Abstract:
Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.
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