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Updated: Jun 17, 2026

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells
Published on: October 4, 2013
Homology modeling studies of yeast Mitogen-Activated Protein Kinases (MAPKS): structural motifs as a basis for
1Oncotech, Inc., 15501 Red Hill Avenue, Tustin, CA 92780, USA. dlsmith@asuragen.com
Abstract:
Mitogen-activated protein kinases (MAPKs) are key components of cellular signal transduction. It is the objective of this communication to demonstrate that insight into protein-protein interactions in the Common Docking motif of yeast mitogen-activated protein kinases can be obtained based on homology models. Homology models for four yeast MAPKs, FUS3, KSS1, HOG1 and MPK1 were built based on the X-ray structures of active and inactive rat ERK2. The structural motifs required for the basis of specificity were rationalized based on these structures.
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