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Related Concept Videos

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Related Experiment Video

Updated: Jun 17, 2026

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

Ovine toxoplasmosis.

Elisabeth A Innes1, Paul M Bartley, David Buxton

  • 1Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ. lee.innes@moredun.ac.uk

Parasitology
|December 10, 2009
PubMed
Summary
This summary is machine-generated.

Congenital toxoplasmosis in sheep, caused by Toxoplasma gondii, leads to abortions. Vaccination with Toxovax offers protection against this significant ovine disease.

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Last Updated: Jun 17, 2026

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
06:33

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

Published on: December 9, 2014

Area of Science:

  • Veterinary Parasitology
  • Immunology
  • Reproductive Biology

Background:

  • Congenital toxoplasmosis, caused by Toxoplasma gondii, is a major global cause of sheep abortion.
  • Cats are definitive hosts, shedding oocysts that contaminate environments, posing infection risks to sheep.
  • Seroprevalence increases with age, suggesting most sheep infections occur post-birth.

Purpose of the Study:

  • To investigate the dynamics of immune responses to Toxoplasma gondii infection in sheep.
  • To understand the critical factors influencing transplacental transmission and clinical outcomes.
  • To evaluate the protective effects of prior infection and vaccination against congenital toxoplasmosis.

Main Methods:

  • Analysis of real-time immune responses using chronic cannulation of peripheral lymph nodes in sheep.
  • Monitoring seroprevalence in sheep populations to correlate with age and infection exposure.
  • Review of existing literature on transplacental transmission and immune protection.

Main Results:

  • Sheep infected before mating develop protective immunity against subsequent pregnancies and experimental challenges.
  • Both innate and adaptive immune systems are activated upon T. gondii infection.
  • The timing of transplacental transmission during gestation significantly impacts fetal outcomes.

Conclusions:

  • Congenital toxoplasmosis is a significant threat to sheep worldwide.
  • Pre-mating infection confers protective immunity in ewes.
  • Toxovax is the sole commercially available vaccine for preventing congenital toxoplasmosis in sheep.