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Updated: Jun 17, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Systemic lupus erythematosus: from pathophysiology to treatment]
C Contin-Bordes1, E Lazaro, J-L Pellegrin
1CNRS UMR 5164, Université Bordeaux2,146 rue Léo Saignat, 33076 Bordeaux, France; Laboratoire d'immunologie, CHU de Bordeaux, Place Amélie Raba Léon 33076 Bordeaux cedex.
La Revue De Medecine Interne
|December 10, 2009
Summary
Systemic lupus erythematosus (SLE) involves a faulty immune response targeting the body's own cells. This review overviews SLE's immune system abnormalities and current/developing treatments.
Area of Science:
- Immunology
- Autoimmunity
- Rheumatology
Context:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disorder.
- Characterized by immune system attacking nuclear components, leading to multiorgan damage.
- Pathogenesis involves genetic susceptibility and environmental triggers, with innate immunity playing a central role.
Purpose:
- To provide an overview of immunological abnormalities in SLE.
- To discuss current and emerging treatments for SLE.
- To highlight the role of innate immunity, dendritic cells, and IFN-alpha in SLE.
Summary:
- SLE involves abnormal innate immune activation, particularly dendritic cells and IFN-alpha secretion.
- Immune complex deposition contributes to inflammation and tissue damage.
- Emerging evidence suggests cytotoxic T-lymphocytes may also play a role in SLE pathogenesis.
Impact:
- Enhances understanding of SLE's complex immunological underpinnings.
- Informs development of targeted therapies for SLE.
- Provides a foundation for future research into SLE pathophysiology and treatment strategies.
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