Related Experiment Video

Updated: Jun 17, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

What have we learnt from targeted anti-TNF therapy?

M Feldmann1, R O Williams, E Paleolog

  • 1Kennedy Institute of Rheumatology Division, Imperial College, 65 Aspenlea Road, London W6 8LH, UK. m.feldmann@imperial.ac.uk

Annals of the Rheumatic Diseases
|December 10, 2009
PubMed

Insights

Anti-tumour necrosis factor (anti-TNF) therapy has been used for rheumatoid arthritis since 1992. This review examines anti-TNF knowledge, gaps, and potential cytokine-based treatments for unmet clinical needs.

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Anti-tumour necrosis factor (anti-TNF) therapy has been a cornerstone in rheumatoid arthritis (RA) treatment since the early 1990s.
  • Extensive research has elucidated the mechanisms by which anti-TNF agents provide therapeutic benefits in RA patients.

Purpose of the Study:

  • To review current knowledge and identify existing gaps in understanding anti-TNF therapy for rheumatoid arthritis.
  • To explore the role of the TNF-dependent cytokine cascade in RA pathogenesis and treatment.
  • To discuss novel therapeutic strategies, including cytokine analysis, for addressing unmet clinical needs in RA.

Main Methods:

  • Literature review of studies on anti-TNF therapy in rheumatoid arthritis.
  • Analysis of the TNF-dependent cytokine cascade and its implications.
  • Exploration of potential new treatment approaches.

Main Results:

  • Significant progress has been made in understanding anti-TNF therapy, but knowledge gaps remain.
  • The TNF-dependent cytokine cascade plays a crucial role in RA.
  • Cytokine analysis may offer new avenues for treating RA and addressing unmet clinical needs.

Conclusions:

  • While anti-TNF therapies have advanced RA treatment, further research is needed to address remaining challenges.
  • Understanding the cytokine network is key to developing more effective and targeted therapies.
  • Cytokine profiling holds promise for personalized medicine and managing refractory RA cases.

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