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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Assessing visual pathway function in multiple sclerosis patients with multifocal visual evoked potentials.

Michal Laron¹, Han Cheng, Bin Zhang

¹University of Houston, College of Optometry, Houston, TX, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|December 10, 2009

Summary

This summary is machine-generated.

Multifocal visual evoked potential (MFVEP) testing effectively detects visual abnormalities in multiple sclerosis (MS) patients. This technique shows high sensitivity and specificity for identifying visual dysfunction in MS, even in those without a history of optic neuritis.

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Area of Science:

Ophthalmology
Neuroscience
Clinical Electrophysiology

Background:

Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system, frequently causing visual impairment.
Optic neuritis is a common initial symptom of MS, but visual abnormalities can also occur without a history of optic neuritis.
Multifocal visual evoked potentials (MFVEP) offer a method for topographic assessment of visual pathway function.

Purpose of the Study:

To assess the diagnostic accuracy of MFVEP in detecting visual abnormalities in patients with MS.
To compare MFVEP results between MS patients with and without a history of optic neuritis, and healthy controls.

Main Methods:

MFVEP recordings were obtained from 74 MS patients with optic neuritis (MS-ON), 71 MS patients without optic neuritis (MS-no-ON), and 100 eyes from 50 healthy controls.
A 60-sector pattern reversal dartboard stimulus (VERIS) was used.
Analysis involved comparing amplitude and latency of each sector to normative data, identifying abnormal clusters (p < 0.05), and evaluating receiver operating characteristic (ROC) curves.

Main Results:

Significant differences in mean amplitudes and latencies were observed between all groups (MS-ON, MS-no-ON, controls) (p < 0.0001).
MS-ON eyes exhibited larger clusters of abnormal sectors compared to MS-no-ON eyes and controls.
MFVEP criteria combining amplitude and latency achieved 91% sensitivity and 95% specificity, with an area under the ROC curve of 0.96.

Conclusions:

MFVEP is a highly sensitive and specific tool for detecting visual function abnormalities in multiple sclerosis patients.
The technique is valuable for identifying subclinical visual pathway damage in MS, regardless of optic neuritis history.
MFVEP contributes significantly to the neuro-ophthalmological assessment of MS.