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Updated: Jun 17, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Gene networks and microRNAs implicated in aggressive prostate cancer
Liang Wang1, Hui Tang, Venugopal Thayanithy
1Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. wang.liang@mayo.edu
None:
Prostate cancer, a complex disease, can be relatively harmless or extremely aggressive. To identify candidate genes involved in causal pathways of aggressive prostate cancer, we implemented a systems biology approach by combining differential expression analysis and coexpression network analysis to evaluate transcriptional profiles using lymphoblastoid cell lines from 62 prostate cancer patients with aggressive phenotype (Gleason grade >or= 8) and 63 prostate cancer patients with nonaggressive phenotype (Gleason grade
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