Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Defining Optimal Sampling Strategies for Cefepime Model-Informed Precision Dosing.

Therapeutic drug monitoring·2026

Same author

Editorial: Unraveling the complexities of premature aging: mechanisms and interventions.

Frontiers in aging·2026

Same author

Time to Treatment Discontinuation and Cost Effectiveness of Third-Line Therapies in Advanced Colorectal Cancer: Real-World Evidence from the NIH All of Us Research Program.

Drugs - real world outcomes·2026

Same author

Modulating AP-1 enables CAR T cells to establish an intratumoral stemlike reservoir and overcomes resistance to PD-1 blockade.

Science immunology·2026

Same author

National Patterns of Biomarker Testing in Colorectal, Lung, and Prostate Cancers: Insights From the NIH <i>All of Us</i> Research Program.

Clinical Medicine Insights. Oncology·2026

Same author

NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Peripheral blood stem cell mobilization tactics.

Lindsay L Rosenbeck¹, Shivani Srivastava, Patrick J Kiel

¹Department of Pharmacy, Simon Cancer Center-Clarian Health, Indiana University, Indianapolis, IN 46202, USA.

The Annals of Pharmacotherapy

|December 10, 2009

Summary

Stem cell mobilization for autologous transplantation uses various methods, with granulocyte colony-stimulating factor (G-CSF) as standard. Plerixafor combined with G-CSF shows improved collection in difficult cases.

More Related Videos

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Related Experiment Videos

Last Updated: Jun 17, 2026

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Area of Science:

Hematology
Transplantation Medicine
Cellular Therapy

Background:

Autologous transplantation relies on successful stem cell mobilization for effective progenitor cell collection.
Mobilization of CD34+ progenitor cells is critical for timely neutrophil and platelet engraftment post-transplant.

Purpose of the Study:

To review current methods and techniques for stem cell mobilization in autologous transplantation.
To evaluate the efficacy and safety of different mobilization strategies.

Main Methods:

Comprehensive literature search of PubMed and MEDLINE databases.
Inclusion of original research, retrospective cohorts, and systematic reviews on stem cell mobilization.
Evaluation of data on plerixafor and hematopoietic growth factors.

Main Results:

Granulocyte colony-stimulating factor (G-CSF) is the current standard for initial mobilization.
Combination therapies, including chemotherapy or plerixafor with G-CSF, are effective for high-risk patients.
Plerixafor plus G-CSF demonstrated superior stem cell collection compared to G-CSF alone in Phase 3 trials.

Conclusions:

The optimal stem cell mobilization strategy remains under investigation.
Colony-stimulating factors are the most frequently used agents.
Chemotherapy or plerixafor in combination with G-CSF offers a viable option for challenging patient populations, including those with non-Hodgkin's lymphoma and multiple myeloma.