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Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation
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Human erythrocyte filterability at low driving pressure.

Shay Ginsbourg1, Shlomo Levin, Shmuel Einav

  • 1Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel.

Clinical Hemorheology and Microcirculation
|December 10, 2009
PubMed
Summary

Human red blood cell (RBC) filterability through capillaries shows a minimum at 25 Pa driving pressure. Below this, filterability unexpectedly increases, suggesting RBCs may spontaneously deform.

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Area of Science:

  • Biophysics
  • Hematology

Background:

  • Red blood cell (RBC) deformability is crucial for microcirculation.
  • Understanding RBC behavior under varying pressures and viscosities is important for diagnosing blood flow disorders.

Purpose of the Study:

  • To model and measure human RBC capillary flow and filterability.
  • To investigate the effect of driving pressure and buffer viscosity on RBC filterability.

Main Methods:

  • A digitally controlled system measured RBC suspension flow through 5 µm Nuclepore filters at constant driving pressures (10-400 Pa).
  • RBC filterability was assessed by normalizing cell suspension flow rate to buffer flow rate.
  • Phosphate buffer solution (PBS) viscosity was varied (1 cP and 2.6 cP).

Main Results:

  • RBC filterability exhibited a nonlinear relationship with driving pressure, with a minimum at 25 Pa.
  • Unexpectedly, RBC filterability increased as driving pressure decreased below 25 Pa, reaching near unity at 10 Pa.
  • Increased PBS viscosity significantly reduced RBC filterability and caused anomalous increases in RBC deformability at 10 Pa.

Conclusions:

  • RBC filterability is pressure-dependent with a minimum at 25 Pa.
  • Spontaneous mechanical fluctuations may explain the anomalous increase in RBC deformability at low pressures.
  • These findings offer insights into RBC behavior in microcapillary flow.