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Published on: September 9, 2020
Exceptional bone metastasis of basal cell carcinoma in Gorlin-Goltz syndrome
Tatiana Lamon1, Stephane Gerard, Nicolas Meyer
1Gérontopôle, Department of Geriatric Medicine, CHU Toulouse, Toulouse, France.
Background:
Basal cell carcinoma (BCC), the most prevalent form of cancer worldwide, is a malignant skin neoplasm. It is locally invasive, with an exceptional incidence of reported metastasis. It can also be part of the Gorlin-Goltz syndrome, an autosomal dominant genetic disorder with high penetrance and variable expressivity, which is principally characterized by cutaneous BCC, odontogenic keratocysts, palmar and/or plantar pits, and falx cerebri calcification.
Observation:
We report the exceptional clinical observation of a 54-year-old man presenting bone metastasis from BCC in Gorlin-Goltz syndrome.
Conclusion:
Less than 300 cases of metastatic BCC have been reported in the literature. The present case is the second associated with Gorlin-Goltz syndrome.
