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Updated: Jun 17, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Synaptic plasticity dynamics in the hippocampal-prefrontal pathway in vivo
Masatoshi Takita1, Yoshinori Izaki, Masahito Kuramochi
1Cognition and Action Research Group, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. takita.m@aist.go.jp
Abstract:
We examined the effect of long-term potentiation (LTP) on paired-pulse responses across varied stimulus intensities and interstimulus intervals (ISIs), at ascending synapses from the intermediate and ventral hippocampus to the medial prefrontal cortex in urethane-anesthetized rats. LTP significantly shifted the median effective stimulus towards lower intensities in the intermediate route, and increased at 25-ms ISI the paired-pulse response, which was inversely proportional to the stimulus intensity. In the ventral route, the paired-pulse response varied with ISI rather than intensity, and increased at 50-ms and 100-ms ISI after LTP. The intermediate synaptic plasticity significantly exhibited total amplifier dynamics with wide ranges of frequency at lower intensity and intensity at 100-ms ISI in contrast to the ventral one.
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