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Related Concept Videos

Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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Related Experiment Video

Updated: Jun 17, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Phenotypic characterization of severe asthma.

Yoshiko Ogawa1, William J Calhoun

  • 1Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Current Opinion in Pulmonary Medicine
|December 10, 2009
PubMed
Summary

Severe asthma is a distinct phenotype often resistant to steroids, requiring higher doses and multiple medications. Emerging research reveals unique mechanisms and potential new therapies for severe asthma management.

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Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

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Last Updated: Jun 17, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Severe asthma represents a significant healthcare burden, characterized by disproportionate utilization and high costs.
  • Improved recognition of severe asthma subsets can lead to enhanced patient care and outcomes.

Purpose of the Study:

  • To review recent literature on severe asthma.
  • To elucidate current understanding of severe asthma's characteristics and potential therapeutic targets.

Main Methods:

  • Literature review of recent studies on severe asthma.
  • Analysis of demographic data, steroid resistance, and molecular associations.
  • Investigation into endogenous anti-inflammatory pathways and protein biomarkers.

Main Results:

  • Severe asthma exhibits distinct demographic profiles and near-universal relative steroid resistance.
  • Associations with interleukin-13 and mammalian chitinase are increasingly recognized.
  • Abnormalities in anti-inflammatory pathways and the utility of protein biomarkers are under investigation.

Conclusions:

  • Severe asthma is a discrete phenotype, often requiring high-dose or multiple controller agents due to common steroid resistance.
  • Distinct mechanistic underpinnings differentiate severe asthma from milder forms.
  • Novel therapeutic interventions may arise from new mechanistic insights.