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Related Concept Videos

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Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
11:17

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Published on: August 24, 2012

Escaping from rejection.

Raymond J Lynch1, Jeffrey L Platt

  • 1Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.

Transplantation
|December 10, 2009
PubMed
Summary
This summary is machine-generated.

Scientists explore natural mechanisms of self-tolerance to prevent immune rejection of transplanted tissues. Studying how organisms avoid self-attack offers insights into improving transplantation therapies.

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Area of Science:

  • Immunobiology
  • Transplantation immunology
  • Natural tolerance mechanisms

Background:

  • Preventing immune recognition and rejection of foreign tissue is a long-standing challenge in transplantation.
  • The goal is to maintain recipient immune function while preventing graft injury.

Purpose of the Study:

  • To explore natural mechanisms of autotoxicity control.
  • To draw parallels between preventing autotoxicity and graft rejection.
  • To identify potential new therapies for allotransplantation and xenotransplantation.

Main Methods:

  • Review of natural mechanisms of autotoxicity control.
  • Comparative analysis of autotoxicity prevention and graft rejection.
  • Discussion of structural and conditional tolerance and accommodation.

Main Results:

  • Natural biological systems possess mechanisms to prevent self-attack (autotoxicity).
  • These mechanisms, including tolerance and accommodation, offer a model for understanding and potentially controlling immune responses in transplantation.

Conclusions:

  • Understanding natural tolerance mechanisms can inform the development of novel strategies for preventing graft rejection.
  • Further research into these natural controls may lead to breakthroughs in allotransplantation and xenotransplantation therapies.