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Development of renal and iliac aneurysms in a child with generalized infantile myofibromatosis

Benoit Brasseur1, Christophe F Chantrain, Nathalie Godefroid

  • 1Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, Brussels, Belgium.

Pediatric Nephrology (Berlin, Germany)
|December 10, 2009
PubMed

Insights

Infantile myofibromatosis can cause severe hypertension and renal artery issues in infants. Chemotherapy helped tumors regress, but artery dilations developed, suggesting a link to fibromuscular dysplasia.

Area of Science:

  • Pediatric Oncology
  • Vascular Biology
  • Rare Diseases

Background:

  • Infantile myofibromatosis is a rare mesenchymal tumor affecting infants.
  • It can manifest with widespread tumors impacting various organs, including the kidneys.
  • Severe hypertension is a potential complication, particularly with renal involvement.

Observation:

  • A 3-week-old infant presented with severe hypertension due to generalized infantile myofibromatosis.
  • The infant received chemotherapy, leading to tumor regression.
  • Aneurysmal dilations of renal and iliac arteries developed during treatment, mimicking fibromuscular dysplasia.

Findings:

  • Successful chemotherapy treatment for infantile myofibromatosis.
  • Development of vascular abnormalities (aneurysmal dilations) post-treatment.
  • Potential association between infantile myofibromatosis and fibromuscular dysplasia.

Implications:

  • Highlights the importance of monitoring vascular health in infants with infantile myofibromatosis.
  • Suggests a possible shared mesenchymal origin or pathway between these two conditions.
  • Warrants further research into the relationship between infantile myofibromatosis and fibromuscular dysplasia.

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