Related Experiment Video
Updated: Jun 17, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
[Role of host genetic factors in gastric carcinogenesis]
Takahiko Kudo1, Tatsuhiko Kane, Haruka Fujinami
1Division of Endoscopy, Toyama University Hospital.
Abstract:
Helicobacter pylori infection is the most common chronic bacterial infection worldwide and the most important acquired risk factor for gastric cancer. Bacterial, environmental and host genetic factors combine to define the degree of gastric damage. The most relevant and consistent genetic factors are in the interleukin-1B and tumor necrosis factor-A gene clusters. These cytokines play a key role in the gastric carcinogenesis and their roles have been confirmed in mouse models. More genetic factors have also been uncovered recently and certain cytokine and innate immune response gene polymorphisms appear to influence risk of gastric cancer and its precursor conditions. In the near future, we will be able to define a more comprehensive genetic profile that would identify high risk groups of developing gastric cancer.
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