[A novel mechanism for H. pylori-induced cell damage--induction of gene mutation by AID]
Tsutomu Chiba1, Hiroyuki Marusawa, Yuko Matsumoto
1Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University.
Abstract:
H. pylori infection causes gastric cancer development through gastritis. However, the precise mechanism for H. pylori-induced carcinogenesis remains unclear. On the other hand, accumulation of gene mutations is a hallmark of cancers, but mechanism of endogenous induction of mutation also remains unknown. Here, we found that H. pylori infection triggers aberrant expression of activation-induced cytidine deaminase (AID), a molecule that can induce DNA somatic hypermutation of immunoglobulin gene in B cells under physiological condition, in the gastric mucosa via NFkappaB-dependent mechanism. Induction of AID then enhances various gene mutations including p53. This mechanism appears to play important roles in gastric carcinogenesis by H. pylori infection.
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