Related Experiment Video
Updated: Jun 17, 2026

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
Published on: April 14, 2011
Tumoral calcinosis in children, a challenging and possibly underdiagnosed condition
Sybille Castelein1, Pierre-Louis Docquier, Jean-Emile Dubuc
1Department of Orthopaedic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Abstract:
Tumoral calcinosis is a rare condition characterized by deposits of calcium hydroxyapatite crystals in periarticular soft tissues. Three clinical settings are possible: complication of renal dialysis, hereditary and sporadic. The condition more commonly affects adults, is rare in children and extremely uncommon in infants. A case of sporadic tumoral calcinosis of the hip is reported in a six-year-old boy for whom the diagnosis was challenging. Surgical treatment was applied because of pain and major functional impairment. A pharmacologic treatment was added for two years. After three years of follow-up, the child was completely asymptomatic and had regained full range of motion. The diagnosis of tumoral calcinosis in children remains challenging.
Related Concept Videos
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Urinary Tract Calculi I: Introduction
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...