Related Experiment Video
Updated: Jun 17, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
Published on: December 2, 2011
Control of protein adsorption onto core-shell tubular and vesicular structures of diphenylalanine/parylene
Gökhan Demirel1, Niranjan Malvadkar, Melik C Demirel
1Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Abstract:
The self-assembly of peptides, specifically dipeptides, offers numerous advantages for biological applications. We describe an easy, versatile method of fabricating different types of zwitterionic Phe-Phe dipeptide structures (i.e., tubes and vesicles) through solvent-mediated assembly. The stability of the dipeptide structures is increased by thin polymer coatings of poly(chloro-p-xylylene), a PPX film. We also investigated protein adsorption onto PPX-coated peptide tubes and vesicles by varying the thickness of the polymer film.
Related Concept Videos
Lipids as Anchors
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...
Pinching-off of Coated Vesicles
Coat Assembly and GTPases
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
Clathrin Coated Vesicles
Protein Folding
Tail-anchoring of Proteins in the ER Membrane

