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Schweinfurthins I and J from Macaranga schweinfurthii
Paul Klausmeyer1, Que N Van, Johnson Jato
1Natural Products Support Group, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.
None:
Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.
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Fungal Group Zygomycota
Fungal Phylum Microsporidia

