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Updated: Jun 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Diversity-oriented synthesis of quinolines via Friedländer annulation reaction under mild catalytic conditions
D Subhas Bose1, Mohd Idrees, N M Jakka
1Organic Chemistry Division-III, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India. dsb@iict.res.in
Abstract:
An efficient and practical method has been manifested for the diversity-oriented synthesis of quinolines via Friedländer annulation reaction for the generation of a wide range of structurally interesting and pharmacologically significant compounds by using ceric ammonium nitrate as a catalyst (10 mol %) at ambient temperature in 45 min. A variety of functional groups are introduced at various positions of the quinoline moiety, and further the diversity of the core skeleton was expanded at R(1) and R(2) positions by the synthesis of various hybrids. Initial screening of the compounds for cytotoxicity against a series of cancer cell lines showed promising results.
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