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Barnes Maze Testing Strategies with Small and Large Rodent Models

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The effects of aging on memory for sequentially presented objects in rats.

Erin Hauser¹, Jerlyn C Tolentino, Eva Pirogovsky

¹Department of Psychology, San Diego State University, San Diego, California 92120-4913, USA.

Behavioral Neuroscience

|December 17, 2009

Summary

Aging impairs temporal order memory in rats. Young rats remember object sequences, but aged rats fail to distinguish between recently and distantly explored objects.

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Area of Science:

Neuroscience
Cognitive Psychology
Gerontology

Background:

Age-related cognitive decline affects memory functions.
Understanding memory changes in aging is crucial for identifying interventions.

Purpose of the Study:

To investigate age-related differences in temporal order memory in rats.
To determine if aging impacts the ability to recall the sequence of experienced events.

Main Methods:

Young (6-month-old) and aged (24-month-old) rats were tested on an object exploration task.
Rats explored object pairs sequentially, followed by a probe test comparing object memory from different time points.

Main Results:

No age-related differences in object exploration during initial trials.
Young rats demonstrated intact temporal order memory, preferring the earlier object.
Aged rats showed no preference, indicating impaired temporal order memory.

Conclusions:

Temporal order memory declines with age in rats.
This decline is not due to reduced exploration, motivation, or locomotion.
Age-related brain changes likely underlie deficits in temporal memory.