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Updated: Jun 17, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

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Published on: May 27, 2015

Targeting CD44 in mast cell regulation.

Satoshi Tanaka¹

¹Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Department of Immunochemistry, Okayama 700-8530, Japan. tanaka@pharm.okayama-u.ac.jp

Expert Opinion on Therapeutic Targets

|December 17, 2009

Summary

This summary is machine-generated.

Mast cells are key immune cells in skin inflammation. This review highlights CD44, a receptor for hyaluronan, as crucial for mast cell differentiation and function in cutaneous immune responses.

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Last Updated: Jun 17, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

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Published on: May 27, 2015

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

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Published on: January 26, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca²⁺-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

Immunology
Dermatology
Cell Biology

Background:

Mast cells are critical immune cells involved in inflammation, immune tolerance, and tumor immunity.
Mast cell heterogeneity in tissues is essential for understanding diverse immune responses.
These cells differentiate from hematopoietic stem cells and reside in tissues.

Purpose of the Study:

To review candidate genes regulating cutaneous mast cell differentiation.
To focus on CD44, the primary receptor for hyaluronan, in this process.

Main Methods:

Literature review of genes involved in cutaneous mast cell differentiation.
Specific focus on the role of CD44 and its interaction with hyaluronan.

Main Results:

CD44 is upregulated during mast cell differentiation and maturation.
CD44 plays a critical role in regulating the number of cutaneous mast cells.
CD44 may modulate local immune responses via cutaneous mast cell functions, especially in chronic inflammation where hyaluronan levels change.

Conclusions:

Understanding cutaneous immune responses necessitates clarifying local mast cell functions.
Extracellular matrix components and their membrane receptors, like CD44, significantly regulate mast cell functions.