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Hematogones: a review and update

Deborah W Sevilla1, Adriana I Colovai, Foxwell N Emmons

  • 1Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA.

Leukemia & Lymphoma
|December 17, 2009
PubMed

Our knowledge regarding the nature and function of 'hematogones' has evolved considerably, since the initial description more than 70 years ago. Once considered the 'mystery cells' of the bone marrow, major advances in immunology and flow cytometry have enabled us to better characterize these cells and recognize them as physiologic precursors of B-cells. In this review, we describe the morphologic and phenotypic characteristics and clinical relevance of hematogones, and report recent advances in our understanding and knowledge of these cells as they relate to physiologic and different pathologic conditions.

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