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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Homing of Hematopoietic Cells to the Bone Marrow
10:40

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Published on: March 18, 2009

Hematogones: a review and update.

Deborah W Sevilla1, Adriana I Colovai, Foxwell N Emmons

  • 1Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA.

Leukemia & Lymphoma
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

Hematogones, once mystery cells, are now understood as physiologic B-cell precursors. Recent advances clarify their characteristics and clinical relevance in health and disease.

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Area of Science:

  • Immunology
  • Hematology
  • Cell Biology

Background:

  • Hematogones were initially described over 70 years ago.
  • Previously considered 'mystery cells' in bone marrow.
  • Advances in immunology and flow cytometry have improved characterization.

Purpose of the Study:

  • To review the morphologic and phenotypic characteristics of hematogones.
  • To discuss the clinical relevance of hematogones.
  • To report recent advances in understanding hematogones in physiologic and pathologic conditions.

Main Methods:

  • Literature review of hematogone research.
  • Analysis of morphologic and phenotypic data.
  • Integration of immunological and flow cytometry findings.

Main Results:

  • Hematogones are identified as physiologic precursors of B-cells.
  • Detailed characterization of hematogone morphology and phenotype.
  • Understanding of hematogones' role in various clinical conditions.

Conclusions:

  • Hematogones are well-defined B-cell precursors.
  • Their clinical significance is increasingly recognized.
  • Ongoing research continues to expand knowledge of hematogones.