Related Experiment Video
Updated: Jun 17, 2026

Stereoacuity Improvement using Random-Dot Video Games
Published on: January 14, 2020
Visual outcome in 879 children treated for strabismus: insufficient accommodation and vision deprivation, deficient
Robert M Ingram1, Trevor W Lambert, Leicester E Gill
1Kettering General Hospital, Northants, United Kingdom. robertingram@tiscali.co.uk
Insights
Early spectacle correction for infant hypermetropia before 18 months can reduce severe residual amblyopia. This intervention addresses vision deprivation and improves outcomes in children with strabismus and refractive errors.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Vision Science
Background:
- Infant hypermetropia is a significant risk factor for developing amblyopia.
- Residual amblyopia after treatment can impact long-term visual development in children.
- Understanding the role of refractive errors in amblyopia is crucial for effective intervention.
Purpose of the Study:
- To determine the impact of infant hypermetropia on the development of residual amblyopia in children.
- To investigate the effectiveness of early spectacle correction in mitigating amblyopia.
- To explore the relationship between refractive error characteristics and visual outcomes.
Main Methods:
- Cycloplegic retinoscopy was performed on 879 strabismic children at 6 months and upon diagnosis.
- Hypermetropic children received consistent spectacle correction from 6 months or had accommodation assessed.
- Statistical analyses (t-tests, regression) correlated clinical findings with visual acuity post-treatment.
Main Results:
- High hypermetropia (> +5.0D) and myopia (> -3.0D) were linked to reduced visual acuity.
- Anisometropia in hypermetropes correlated with worse amblyopia; astigmatism was associated with myopia.
- Early spectacle wear (by 18 months) improved vision in the nonfixing eye.
Conclusions:
- Severe residual amblyopia may stem from additional vision deprivation, exacerbated by hypermetropia.
- Initiating spectacle correction for hypermetropia before 18 months can decrease amblyopia severity.
- Anisometropia appears to result from impaired emmetropization processes.
Purpose:
To identify the effect of infant hypermetropia on residual amblyopia in children remaining after treatment.
Materials And Methods:
879 strabismic children had cycloplegic retinoscopy at the age of 6 months and later when strabismus was diagnosed. A total of 26 hypermetropes consistently wore glasses from the age of 6 months, and 305 other hypermetropes had their accommodation periodically assessed by dynamic retinoscopy before strabismus was diagnosed. The relation between the last known visual acuity after treatment and all other clinical findings was analysed using t-tests and regression analysis.
Results:
Vision less than 6/12 in nonfixing eyes was associated with infantile hypermetropia > +5.0D, and in rare instances in excess of -3.0D of myopia. In hypermetropes only, anisometropia was associated with worse amblyopia. Astigmatism was associated with myopia and low levels of hypermetropia but not with worse vision. The vision of fixing eyes that were hypermetropic was significantly worse than that of emmetropic or myopic eyes. Wearing spectacles from the age of 6 months was associated with better vision in the nonfixing eye. Vision in the nonfixing eye of 19 hypermetropic heterotropes who started wearing glasses between 6 and 18 months of age also was better than that of those who started wearing glasses after 18 months of age. Insufficiency of accommodation was related to the degree of infantile hypermetropia, to worse vision and to failure to emmetropise. Difference in amplitude of accommodation between the eyes was largest in hypermetropes with anisometropia > +1.50 D and was marginally associated with worse vision in microtropes who became anisometropic after infancy. Hypermetropia decreased more in fixing eyes than in nonfixing eyes, thereby causing anisohypermetropia to increase after infancy. This change was most pronounced in hypermetropic microtropes. Conversely, failure of fixing eyes to emmetropise was associated with an increase in their inability to accommodate and heterotropia.
Conclusions:
On the basis of these findings, severe residual amblyopia in children remaining after treatment could be explained by additional vision deprivation. It can be reduced by starting spectacle correction of hypermetropia before the age of 18 months. Anisometropia seemed the result of deficient emmetropisation.
Related Concept Videos
Focusing of Light in the Eye
Photoreceptors and Visual Pathways
Accessory Structures of the Eye
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
