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Clinical safety of ranibizumab in age-related macular degeneration

Ursula Schmidt-Erfurth1

  • 1Medical University of Vienna, Department of Ophthalmology, Waehringer Guertel 18-20, A-1090 Vienna, Austria. ursula.schmidt-erfurth@meduniwien.ac.at

Expert Opinion on Drug Safety
|December 17, 2009
PubMed
Abstract

Insights

Repeated intravitreal ranibizumab injections showed good tolerability in patients, with no significant safety risks observed over two years. Further research is needed to fully understand potential stroke risks associated with ranibizumab therapy.

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Elderly patients face higher risks for cardiac and other adverse events from pharmaceutical products.
  • Ensuring clinical safety in this demographic is crucial.

Purpose of the Study:

  • To review the clinical safety of pharmaceutical products in the elderly.
  • To assess ocular and systemic risks associated with ranibizumab therapy.

Main Methods:

  • A comprehensive search of the Medline database was conducted.
  • Articles and abstracts published from 1984 to 2009 were included.

Main Results:

  • Endophthalmitis rates were low (0.05%-0.1% per injection).
  • Transient, moderate intraocular pressure increases and rare serious inflammation were noted.
  • Systemic thromboembolic events showed no significant difference between ranibizumab and sham treatments, though a non-significant trend for stroke was observed in some patient groups.

Conclusions:

  • Repeated intravitreal ranibizumab demonstrated good tolerability and no clinically significant safety risks up to two years.
  • Further investigation into the stroke risk with ranibizumab therapy is warranted.

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