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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Introduction01:26

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model
09:31

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Published on: November 9, 2018

Signaling pathways associated with inflammatory bowel disease.

Jia Wei1, Jiexiong Feng

  • 1Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China.

Recent Patents on Inflammation & Allergy Drug Discovery
|December 17, 2009
PubMed
Summary

This review explores signaling pathways involved in inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis. Understanding these pathways offers new therapeutic targets for IBD treatment.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Molecular Biology

Background:

  • Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), arises from complex genetic and environmental factors.
  • Key contributors include aberrant immune responses, intestinal barrier dysfunction, and interactions with enteric bacteria.
  • Specific signaling pathways are implicated in the inflammatory processes driving IBD pathogenesis.

Purpose of the Study:

  • To review current understanding of signaling pathways in IBD pathogenesis.
  • To highlight recent patents related to IBD signaling pathways.
  • To provide insights for developing novel therapeutic strategies for IBD.

Main Methods:

  • Literature review focusing on signaling pathways in IBD.
  • Analysis of relevant patents concerning IBD therapeutics.
  • Synthesis of information on molecular mechanisms and microbial roles.

Main Results:

  • Identified key signaling pathways: P38 MAPK, JNK MAPK, PI3K/Akt, and NF-kappaB.
  • Demonstrated the role of disordered signaling pathways (e.g., TLR, NF-kappaB) in intestinal barrier dysfunction.
  • Highlighted the link between signaling pathway dysregulation and effector T cell release in CD.

Conclusions:

  • Signaling pathways are central to IBD pathogenesis, influencing inflammation and immune response.
  • Intestinal microorganisms and barrier function are modulated by these pathways.
  • Further research into IBD signaling pathways and patent landscape can guide the development of targeted therapies.