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Updated: Jun 17, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Insights on the structure of amyloid fibrils from site-directed mutagenesis
Daniel Henrique do Amaral Corrêa1, Carlos Henrique Inácio Ramos
1Institute of Chemistry and Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagem, Brazil.
Abstract:
To test the hypothesis that the ability to form ordered beta-rich amyloid fibers with identical structures is a generic property of proteins we present a study on the overall structures of fibers formed by apomyoglobin mutants that either stabilize or destabilize the native state or the intermediate. Our results indicate that, at least at the macroscopic level, ordered beta-rich amyloid fibers have similar structures.
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