Related Experiment Video

Updated: Jun 17, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

[The syndrome of mitral regurgitation in patients with chronic heart failure]

V N Larina, M N Alekhin, B Ia art

    Kardiologiia
    |December 17, 2009
    PubMed

    Insights

    Functional mitral regurgitation frequently complicates ischemic heart disease, worsening chronic heart failure (CHF). Left ventricular remodeling disrupts valve function, determining the severity of this common complication in systolic dysfunction.

    Area of Science:

    • Cardiology
    • Cardiac Surgery
    • Heart Failure Research

    Context:

    • Functional mitral regurgitation (FMR) is a common complication in patients with ischemic heart disease (IHD).
    • FMR significantly contributes to the progression of chronic heart failure (CHF).
    • Systolic left ventricular dysfunction is present in a substantial number of patients with FMR.

    Purpose:

    • To elucidate the role of functional mitral regurgitation in the pathophysiology of chronic heart failure.
    • To understand the relationship between left ventricular remodeling and the severity of mitral regurgitation.
    • To investigate the impact of altered mitral valve dynamics on heart failure progression.

    Summary:

    • Functional mitral regurgitation affects 18.9% of patients with severe systolic left ventricular dysfunction.
    • Moderate mitral regurgitation is observed in 29.7% of patients with systolic left ventricular dysfunction.
    • Left ventricular remodeling is a key factor in the development of FMR, impairing ventricular-valvular coordination.

    Impact:

    • Understanding FMR's role is crucial for managing heart failure patients with IHD.
    • Identifying the mechanisms of FMR can lead to improved therapeutic strategies.
    • This research highlights the importance of assessing mitral valve function in systolic dysfunction.

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