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Ninhydrin thiohemiketals: basic research towards improved fingermark detection techniques employing nano-technology.

Joseph Almog¹, Hagai Glasner

¹Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. almog@vms.huji.ac.il

Journal of Forensic Sciences

|December 17, 2009

Summary

Researchers explored novel ninhydrin derivatives for enhanced fingerprint visualization using gold nanoparticles (NP). Ninhydrin thiohemiketals (THK) successfully developed latent fingerprints, showing promise for advanced forensic technology.

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Area of Science:

Forensic Science
Nanotechnology
Organic Chemistry

Background:

Current fingerprint visualization methods can be improved for selectivity and efficiency.
Gold nanoparticles (NP) offer potential for enhanced detection but require specific binding strategies.
Ninhydrin and 1,2-indanedione are established fingerprint reagents.

Purpose of the Study:

To synthesize and evaluate novel ninhydrin and 1,2-indanedione derivatives for selective binding to fingerprint residues.
To investigate the potential of these derivatives for use with gold nanoparticles in fingerprint visualization.
To explore the formation of thiol groups for nanoparticle stabilization.

Main Methods:

Synthesis of ninhydrin thiohemiketals (THK) and 1,2-indanedione thioketals.

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Testing of synthesized compounds with amino acids to assess reactivity.

Application of compounds to develop latent fingerprints on paper.

Evaluation of reaction byproducts for gold nanoparticle stabilization potential.

Main Results:

Ninhydrin THK derivatives reacted with amino acids, producing Ruhemann's purple.
Ninhydrin THK successfully developed latent fingerprints on paper, similar to traditional ninhydrin.
1,2-indanedione ketals and thioketals showed no reaction with amino acids or latent fingerprints.
Potential for thiol byproducts to stabilize gold nanoparticles was identified.

Conclusions:

Ninhydrin thiohemiketals are promising reagents for latent fingerprint development.
The synthesized compounds offer a pathway for more selective nanoparticle-based fingerprint visualization.
Further research will focus on utilizing thiol byproducts for covalent gold NP binding to fingerprint ridges.