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Related Experiment Video

Updated: Jun 17, 2026

Intramyocardial Cell Delivery: Observations in Murine Hearts

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

Recirculating delivery improves myocardial cell engraftment.

Melissa J Byrne¹, Amanda Zatta, Cesere Galli

¹Heart Failure Research Group, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia. melissa.byrne@bakeridi.edu.au

Journal of Interventional Cardiology

|December 17, 2009

Summary

This summary is machine-generated.

The V-Focus system significantly improves cell delivery to the ovine heart compared to direct coronary infusion. This novel cardiac delivery method offers a promising solution for cell therapy in heart failure treatment.

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Published on: June 18, 2018

Area of Science:

Cardiovascular Research
Regenerative Medicine
Surgical Technology

Background:

Heart failure remains a leading cause of mortality despite advances in pharmacotherapy.
Cell therapy presents a promising alternative, but efficient cardiac cell delivery is a significant challenge.
Optimizing cell delivery is crucial for the success of cardiac regenerative medicine.

Purpose of the Study:

To evaluate the efficacy of a percutaneous recirculation system (V-Focus) for cell delivery to the heart.
To compare the V-Focus system with traditional intracoronary (IC) infusion for cardiac cell delivery.
To assess the feasibility of using the V-Focus system in a large animal model.

Main Methods:

Ovine fibroblasts (3 x 10^7 cells) were delivered to ovine hearts using either the V-Focus system or IC infusion.
The V-Focus system is a closed recirculatory system involving coronary sinus blood draw and return via an oxygenator to the coronary artery.
Cardiac tissue was collected post-procedure for cell presence analysis.

Main Results:

The V-Focus system demonstrated significantly higher cell delivery to the left ventricular freewall (1.39 vs 0.11 cells/mm^2), septum (3.18 vs 0.38 cells/mm^2), and right ventricle (0.46 vs 0.05 cells/mm^2) compared to IC infusion (P < 0.05).
These findings indicate a superior distribution and retention of cells within the cardiac tissue using the V-Focus system.
The system proved effective in delivering therapeutic cells to various regions of the large animal heart.

Conclusions:

The V-Focus cardiac delivery system facilitates optimal delivery of therapeutic cells to the large animal heart.
This percutaneous recirculation system represents a significant advancement in cardiac cell delivery techniques.
The V-Focus system holds potential for improving the efficacy of cell-based therapies for cardiac conditions.