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Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
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Chronic partial bladder outlet obstruction does not impair erectile function in male rats.

Nicholas Aldridge1, Hyun Woo Kim, Amir Motamedi

  • 1Department of Medicine, University of California and Veterans Medical Research Foundation, La Jolla, San Diego, CA 92161, USA.

BJU International
|December 17, 2009
PubMed
Summary

Partial bladder outlet obstruction (PBOO) in rats did not impair erectile function, despite causing bladder changes. Further research is needed to understand human lower urinary tract symptom-related erectile dysfunction.

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Area of Science:

  • Urology
  • Andrology
  • Physiology

Background:

  • Partial bladder outlet obstruction (PBOO) is associated with lower urinary tract symptoms.
  • The impact of PBOO on erectile function requires further elucidation.
  • Animal models are crucial for investigating the mechanisms underlying PBOO-induced changes.

Purpose of the Study:

  • To investigate the effect of surgically induced PBOO on erectile function in a rat model.
  • To assess urodynamic and erectile responses following PBOO.
  • To explore potential molecular changes in bladder and penile tissues.

Main Methods:

  • PBOO was surgically induced in Sprague-Dawley rats by partial urethral ligation.
  • Urodynamic and erectile functions were evaluated at 4-8 weeks post-surgery.

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  • Erectile responses were measured using electrical field stimulation and erectogenic agents, with area under the curve (AUC) quantifying the response.

    • Main Results:

    • PBOO significantly increased bladder weight and voiding frequency in rats compared to sham controls.
    • No significant differences were observed in erectile responses to electrical field stimulation or erectogenic agents between PBOO and sham groups.
    • Increased RhoA immunoreactivity was noted in the bladder and penile tissues of PBOO rats.

    Conclusions:

    • Surgically induced PBOO in rats does not adversely affect erectile function.
    • The findings suggest that PBOO itself may not be a direct cause of erectile dysfunction in this model.
    • Additional mechanisms may be involved in the development of erectile dysfunction associated with lower urinary tract symptoms in humans.