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Updated: Jun 17, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Primary seminoma of the prostate.
Takeshi Hashimoto1, Makoto Ohori, Noboru Sakamoto
1Department of Urology, Tokyo Medical University, Tokyo, Japan.
Summary
This case report details a rare primary prostate seminoma, initially misdiagnosed as sarcoma. Successful treatment with chemotherapy led to a complete response, highlighting a unique clinical presentation.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Prostate cancer diagnosis can be challenging, with rare tumors mimicking common presentations.
- Sarcomas and germ cell tumors are uncommon in the prostate.
Observation:
- A 54-year-old male presented with a low prostate-specific antigen (PSA) and a heterogeneous prostate mass on imaging.
- Initial suspicion was for prostate sarcoma due to imaging findings.
Findings:
- Prostate needle biopsy and immunohistochemistry confirmed primary seminoma, a rare germ cell tumor of the prostate.
- The patient had no evidence of extragonadal disease.
- Complete response was achieved after three cycles of bleomycin, etoposide, and cisplatin chemotherapy.
Implications:
- This case adds to the limited literature on primary prostate seminoma, emphasizing the importance of thorough pathological examination.
- Early diagnosis and appropriate chemotherapy can lead to favorable outcomes in rare prostate malignancies.
- Further research into the etiology and optimal management of primary prostate germ cell tumors is warranted.
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