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Related Experiment Video

Updated: Jun 17, 2026

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

Published on: July 14, 2017

Circulating free nitrotyrosine and cognitive decline.

L Coppola¹, A Pastore, G Adamo

¹Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy. ludovico.coppola@unina2.it

Acta Neurologica Scandinavica

|December 17, 2009

Summary

This summary is machine-generated.

Elevated nitrotyrosine levels correlate with lower cognitive function in impaired individuals. This finding may aid in managing Mild Cognitive Impairment, a precursor to dementia.

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Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

Published on: January 30, 2019

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Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications

Published on: July 14, 2017

Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System

Published on: January 30, 2019

Area of Science:

Biochemistry
Neuroscience
Gerontology

Background:

Oxidative stress and inflammation are implicated in cognitive decline.
Nitrotyrosine is a marker of oxidative stress.

Purpose of the Study:

To investigate the correlation between circulating nitrotyrosine levels and cognitive function.
To assess the relationship in community-living adults across a wide age range.

Main Methods:

Evaluated 112 subjects (aged 27-98) for cognitive abilities using the Mini Mental State Examination (MMSE).
Measured circulating free nitrotyrosine plasma levels.
Controlled for confounding variables like age, education, BMI, and cardiovascular/inflammatory markers.

Main Results:

A significant inverse correlation was found between nitrotyrosine levels and MMSE scores in cognitively impaired subjects (MMSE < 23.9).
No significant correlation was observed in cognitively unimpaired subjects.

Conclusions:

Circulating nitrotyrosine may serve as a potential biomarker for cognitive impairment.
Further longitudinal studies are needed to confirm these findings and explore implications for Mild Cognitive Impairment management.