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Related Experiment Video

Updated: Jun 17, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

The effect of ascorbate on minor recurrent aphthous stomatitis.

K Yasui¹, T Kurata, M Yashiro

¹Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. k-yasui@md.okayama-u.ac.jp

Acta Paediatrica (Oslo, Norway : 1992)

|December 17, 2009

Summary

Vitamin C (ascorbate) supplementation significantly reduced the frequency of minor recurrent aphthous stomatitis (MRAS) outbreaks and associated pain in children. This study suggests ascorbate may be an effective treatment for MRAS.

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Last Updated: Jun 17, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

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Published on: April 11, 2014

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Published on: February 23, 2019

Area of Science:

Oral Medicine
Immunology
Nutritional Science

Background:

Minor recurrent aphthous stomatitis (MRAS) is a prevalent, painful oral inflammatory condition with juvenile onset and unknown causes.
Polymorphonuclear leukocytes are implicated in the pathogenesis of MRAS.

Purpose of the Study:

To investigate the efficacy of ascorbate (vitamin C) in reducing MRAS outbreak frequency and pain severity.
To explore ascorbate's potential role in modulating neutrophil function in MRAS patients.

Main Methods:

A crossover clinical trial involving 16 pediatric patients with MRAS.
Patients received an oral dosage of 2000 mg/m(2)/day of ascorbate.
Superoxide anion production by polymorphonuclear leukocytes was evaluated pre-treatment.

Main Results:

A statistically significant 50% reduction in oral ulcer outbreaks was observed.
A notable decline in pain levels associated with MRAS was reported.
Neutrophils in MRAS patients showed priming for superoxide anion production.

Conclusions:

Ascorbate may mitigate neutrophil-mediated inflammation by modulating reactive oxygen species generation and promoting neutrophil apoptosis.
Preliminary findings suggest ascorbate is effective for MRAS, but further large-scale randomized controlled trials are warranted.