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Related Experiment Video

Updated: Jun 17, 2026

Gastrointestinal Motility Monitor (GIMM)

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

Opiate-induced oesophageal dysmotility.

R E Kraichely¹, A S Arora, J A Murray

¹Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. kraichely.robert@mayo.edu

Alimentary Pharmacology & Therapeutics

|December 17, 2009

Summary

Opiate use can cause esophageal motility abnormalities, including impaired lower esophageal sphincter relaxation and non-peristaltic contractions, leading to dysphagia. These effects often resolve when opiates are discontinued, suggesting caution in diagnosing primary esophageal disorders.

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Area of Science:

Gastroenterology
Pharmacology
Esophageal Physiology

Background:

Opiates are known to cause gastrointestinal issues like opioid bowel dysfunction.
Clinical effects of opiates on esophageal motor function are poorly understood.

Purpose of the Study:

To characterize the effects of opiate use on esophageal motor function in patients experiencing dysphagia.

Main Methods:

Retrospective review of 15 patients with dysphagia on chronic opiates.
Esophageal manometry performed during opiate use and, in three cases, after discontinuation.

Main Results:

All patients showed esophageal motility abnormalities, including incomplete lower esophageal sphincter (LOS) relaxation and non-peristaltic contractions.
Abnormalities included high amplitude/velocity contractions and hypertensive LOS.
Repeat manometry off opiates showed improved LOS relaxation and peristalsis.

Conclusions:

Opiate use is associated with a range of esophageal manometric abnormalities.
These findings suggest the esophagus is susceptible to opiate effects.
Caution is advised before diagnosing primary esophageal motility disorders in patients taking opiates.