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Gender differences in presentation and diagnosis of chest pain in primary care
Stefan Bösner1, Jörg Haasenritter, Maren A Hani
1Department of General Practice/Family Medicine, University of Marburg, 35032 Marburg, Germany. boesner@staff.uni-marburg.de
Insights
Men are more likely to have Coronary Heart Disease (CHD) than women, but chest pain symptoms differ by gender. Understanding these differences in primary care is crucial for accurate diagnosis and treatment.
Area of Science:
- Cardiology
- Primary Care Medicine
- Gender Studies
Background:
- Chest pain is a frequent reason for primary care visits.
- Existing research on gender differences in Coronary Heart Disease (CHD) primarily focuses on hospital settings, not primary care.
- This study addresses the gap by examining gender disparities in chest pain aetiology and clinical presentation within primary care.
Purpose of the Study:
- To analyze gender differences in the causes and clinical characteristics of chest pain.
- To identify gender-specific symptoms and signs associated with Coronary Heart Disease (CHD).
- To inform potential gender-tailored diagnostic strategies for chest pain in primary care.
Main Methods:
- 1212 patients aged 35+ presenting with chest pain to 74 general practitioners (GPs) were included.
- GPs collected patient symptoms and findings, with follow-up data.
- An independent panel reviewed clinical data to determine chest pain aetiology; multivariable regression identified CHD predictors.
Main Results:
- Men had higher rates of CHD (17.2%) compared to women (13.0%).
- Women more frequently presented with psychogenic disorders, while men showed higher rates of trauma and pneumonia/pleurisy.
- Specific symptoms like pain duration and location were differentially associated with CHD in men versus women.
Conclusions:
- Significant gender differences exist in chest pain aetiology and clinical characteristics within primary care.
- Symptoms associated with Coronary Heart Disease (CHD) vary between men and women.
- Further research is needed to determine if gender-specific diagnostic approaches for CHD are warranted.
Background:
Chest pain is a common complaint and reason for consultation in primary care. Research related to gender differences in regard to Coronary Heart Disease (CHD) has been mainly conducted in hospital but not in primary care settings. We aimed to analyse gender differences in aetiology and clinical characteristics of chest pain and to provide gender related symptoms and signs associated with CHD.
Methods:
We included 1212 consecutive patients with chest pain aged 35 years and older attending 74 general practitioners (GPs). GPs recorded symptoms and findings of each patient and provided follow up information. An independent interdisciplinary reference panel reviewed clinical data of every patient and decided about the aetiology of chest pain at the time of patient recruitment. Multivariable regression analysis was performed to identify clinical predictors that help to rule in or out CHD in women and men.
Results:
Women showed more psychogenic disorders (women 11,2%, men 7.3%, p = 0.02), men suffered more from CHD (women 13.0%, men 17.2%, p = 0.04), trauma (women 1.8%, men 5.1%, p < 0.001) and pneumonia/pleurisy (women 1.3%, men 3.0%, p = 0.04) Men showed significantly more often chest pain localised on the right side of the chest (women 9.1%, men 25.0%, p = 0.01). For both genders known clinical vascular disease, pain worse with exercise and age were associated positively with CHD. In women pain duration above one hour was associated positively with CHD, while shorter pain durations showed an association with CHD in men. In women negative associations were found for stinging pain and in men for pain depending on inspiration and localised muscle tension.
Conclusions:
We found gender differences in regard to aetiology, selected clinical characteristics and association of symptoms and signs with CHD in patients presenting with chest pain in a primary care setting. Further research is necessary to elucidate whether these differences would support recommendations for different diagnostic approaches for CHD according to a patient's gender.
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