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Related Experiment Videos

Abnormal liver enzyme levels. Evaluation in asymptomatic patients.

P D King1

  • 1Department of Medicine, University of Missouri-Columbia School of Medicine 65212.

Postgraduate Medicine
|March 1, 1991
PubMed
Summary

Persistent elevation of liver enzymes like aminotransferases or alkaline phosphatase can indicate serious liver or biliary conditions. Early detection through history, examination, and tests aids in diagnosing unsuspected liver disease.

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Clinical Diagnostics

Background:

  • Chronic elevation of serum aminotransferase levels suggests underlying liver disease, including chronic hepatitis.
  • Persistently abnormal alkaline phosphatase may indicate extrahepatic biliary tract disease or cholestatic disorders.

Purpose of the Study:

  • To outline a strategy for physicians to detect unsuspected liver disease.
  • To emphasize non-invasive and cost-effective diagnostic approaches.

Main Methods:

  • Detailed patient history and physical examination.
  • Judicious timing of follow-up blood tests.
  • Timely referral for liver biopsy or ERCP when indicated.

Main Results:

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  • Unsuspected liver disease can be identified without significant patient risk, expense, or inconvenience.
  • A systematic approach ensures thorough evaluation of abnormal liver function tests.

    • Conclusions:

    • Early identification of chronic liver and biliary conditions is achievable through a combination of clinical assessment and targeted investigations.
    • Prompt diagnosis facilitates timely management of significant liver pathology.