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Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Vaccinations01:51

Vaccinations

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...

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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
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Vaccination for respiratory immunity: latest developments.

Richard Harland1

  • 1Novartis Animal Health Canada, Inc., Calgary, Alberta T2V 4M6, Canada. richard.harland@novartis.com

Animal Health Research Reviews
|December 17, 2009
PubMed
Summary

Recent advances in immunology and molecular biology offer new vaccine strategies for respiratory diseases. These innovations promise safer, more effective, and flexible vaccine options through improved antigen identification and delivery methods.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Vaccinology

Background:

  • Significant progress in immunology and molecular biology over the past two decades.
  • Development of novel tools for antigen identification and immune response modulation.

Purpose of the Study:

  • To review the advancements in vaccine development for respiratory diseases.
  • To highlight new strategies for antigen discovery and immune response induction.

Main Methods:

  • Utilizing deletion mutations, subunit antigens, vectors, and DNA immunization.
  • Employing advanced screening and production techniques for antigens.
  • Incorporating novel adjuvants for enhanced immune responses.

Main Results:

  • Increased options for generating optimal immune responses.
  • Improved methods for antigen screening, discovery, and production.
  • Development of more effective delivery systems for vaccine antigens.

Conclusions:

  • New vaccine technologies lead to safer and more efficacious respiratory disease vaccines.
  • Enhanced flexibility in vaccine use and administration is anticipated.
  • These advancements represent a significant step forward in combating respiratory illnesses.