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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Lymphogranuloma venereum in Europe, 2003-2008
E J Savage1, M J van de Laar, A Gallay
1Health Protection Agency, Centre for Infections, HIV and STI Department, London, United Kingdom.
Summary
Lymphogranuloma venereum (LGV), a Chlamydia trachomatis infection, has seen increasing cases in Europe since 2003. Patient characteristics remained consistent during the 2003-2008 study period.
Area of Science:
- Infectious Diseases
- Public Health Epidemiology
- Sexually Transmitted Infections
Background:
- Lymphogranuloma venereum (LGV), caused by specific serovars of Chlamydia trachomatis, re-emerged in Europe in 2003.
- Outbreaks primarily affected men who have sex with men (MSM), often presenting with severe proctitis and co-infections like HIV.
Purpose of the Study:
- To review the epidemiological trends and case numbers of LGV in Europe between 2003 and 2008.
- To analyze the characteristics of LGV patients across European countries during the initial five years of the outbreak.
Main Methods:
- Data collection from the European Surveillance of Sexually Transmitted Infections (ESSTI) network.
- Inclusion of reported LGV cases from nine European countries (Belgium, Denmark, France, Germany, the Netherlands, Portugal, Spain, Sweden, UK).
- Analysis of case numbers and patient demographics over a five-year period (2003-2008).
Main Results:
- An overall increase in the total number of reported LGV cases across Europe.
- Expansion of LGV detection to more European countries within the study timeframe.
- Consistent patient demographics and clinical presentation observed throughout the five-year period.
Conclusions:
- LGV incidence in Europe showed an upward trend from 2003 to 2008.
- The primary demographic affected by LGV remained consistent.
- Continued surveillance is crucial for monitoring the spread and impact of LGV in Europe.
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