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Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children

Lucy Chai See Lum1, Charissa Fay Borja-Tabora, Robert F Breiman

  • 1Department of Pediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Vaccine
|December 17, 2009
PubMed

Insights

Live attenuated influenza vaccine (LAIV) given with measles, mumps, and rubella vaccine (Priorix) showed lower rubella response rates in children. However, LAIV maintained its effectiveness in preventing influenza.

Area of Science:

  • Pediatric Vaccinology
  • Immunology
  • Infectious Diseases

Background:

  • Live attenuated influenza vaccine (LAIV) is an alternative to inactivated influenza vaccines.
  • Combined vaccines are often administered to children to improve vaccination coverage.
  • Assessing vaccine-school interactions is crucial for understanding immune responses.

Purpose of the Study:

  • To evaluate the immunogenicity of LAIV when co-administered with the measles, mumps, and rubella (MMR) vaccine (Priorix) in children.
  • To determine if concomitant administration affects the efficacy of either vaccine.
  • To assess seroresponse rates for measles, mumps, and rubella.

Main Methods:

  • Children aged 11 to 24 months received two doses of intranasal LAIV or placebo, 35 days apart.
  • The first dose of LAIV was given concurrently with Priorix.
  • Seroresponse rates were measured using specified antibody thresholds (15 IU/mL and 10 IU/mL for rubella).

Main Results:

  • Seroresponses to measles and mumps were comparable between the LAIV+Priorix and placebo groups.
  • Rubella response rates were statistically lower in the LAIV+Priorix group at a 15 IU/mL threshold, failing to meet noninferiority criteria.
  • At a 10 IU/mL threshold, noninferiority for rubella response was met.
  • Concomitant administration did not impact the overall influenza protection rate of LAIV.

Conclusions:

  • Co-administration of LAIV with Priorix may impact rubella immunogenicity, although this effect is threshold-dependent.
  • LAIV retains its protective efficacy against influenza when given alongside the MMR vaccine.
  • Further research may be needed to fully understand the implications of combined vaccine administration on specific immune responses.

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