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Updated: Jun 17, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Hemorrhagic encephalitis associated with Epstein-Barr virus infection.

Satoru Takeuchi¹, Yoshio Takasato, Hiroyuki Masaoka

¹Department of Neurosurgery, National Hospital Organization Disaster Medical Center, 3256 Midori-cho, Tachikawa-shi, Tokyo 190-0014, Japan. s.takeuchi@room.ocn.ne.jp

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|December 17, 2009

Summary

This case study reports a rare instance of hemorrhagic Epstein-Barr virus (EBV) encephalitis in a young adult male. Diagnosis was confirmed via PCR on brain biopsy, highlighting EBV

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Last Updated: Jun 17, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Area of Science:

Neurology
Infectious Diseases
Virology

Background:

Epstein-Barr virus (EBV) is a common herpesvirus, typically causing infectious mononucleosis.
Neurological complications, such as encephalitis, are rare sequelae of EBV infection.
Hemorrhagic encephalitis is an even rarer presentation, predominantly documented in pediatric populations.

Observation:

A previously healthy 20-year-old male presented with a week of fever, diarrhea, headache, and confusion.
Initial brain MRI revealed a focal lesion in the right temporal lobe.
Subsequent imaging demonstrated lesion progression with hemorrhagic changes, brain swelling, and midline shift.

Findings:

The patient underwent surgical intervention, including external decompression and external ventricular drainage.
Polymerase chain reaction (PCR) analysis of brain biopsy specimens confirmed the presence of Epstein-Barr virus DNA.
This case represents the second documented instance of hemorrhagic EBV encephalitis in an adult.

Implications:

This report expands the understanding of EBV's potential neurological manifestations in adults.
It underscores the importance of considering EBV in the differential diagnosis of encephalitis, even in non-pediatric patients.
Early diagnosis and intervention may be crucial for managing severe neurological complications of EBV.