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Updated: Jun 17, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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[Hypofractionated stereotactic radiotherapy for brain metastases].

M Schlienger1, F Nataf, F Huguet

  • 1Service d'oncologie-radiothérapie, hôpital Tenon, 4 rue de la Chine, Paris, France. michel.schlienger@tnn.aphp.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 17, 2009
PubMed
Summary

Both radiosurgery and hypofractionated stereotactic radiotherapy are effective for treating brain metastases larger than 500 mm³. For smaller lesions, radiosurgery with invasive immobilization is preferred, while larger tumors may benefit from hypofractionated radiotherapy.

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Context:

  • Brain metastases pose a significant challenge in cancer treatment.
  • Choosing between radiosurgery and hypofractionated stereotactic radiotherapy is crucial for optimal patient outcomes.
  • Literature review identifies key parameters for treatment selection.

Purpose:

  • To compare radiosurgery and hypofractionated stereotactic radiotherapy for brain metastases.
  • To provide evidence-based guidance for treatment modality selection.
  • To analyze efficacy and toxicity based on tumor volume and treatment parameters.

Summary:

  • Hypofractionated stereotactic radiotherapy and radiosurgery demonstrated similar efficacy for brain metastases between 500-4200 mm³ GTV.
  • Radiosurgery with invasive immobilization is recommended for smaller lesions (<500 mm³).
  • Hypofractionated stereotactic radiotherapy may be suitable for larger lesions (>4200 mm³) with further study.

Impact:

  • Informs clinical decision-making for brain metastases treatment.
  • Highlights the importance of tumor size and immobilization technique in treatment planning.
  • Suggests future research directions for optimizing hypofractionated stereotactic radiotherapy parameters.