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Constipation in pediatric cystic fibrosis patients: an underestimated medical condition

H P J van der Doef1, F T M Kokke, F J A Beek

  • 1Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands. H.P.J.vanderdoef@umcutrecht.nl <H.P.J.vanderdoef@umcutrecht.nl>

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|December 17, 2009
PubMed

Insights

Constipation affects nearly half of pediatric Cystic Fibrosis (CF) patients, linked to poor fat absorption and meconium ileus. Abdominal X-rays offer limited value for routine CF care.

Area of Science:

  • Gastroenterology
  • Pediatrics
  • Pulmonology

Background:

  • Constipation is a common complication in Cystic Fibrosis (CF).
  • Understanding its prevalence, risk factors, and diagnostic tools is crucial for patient management.
  • Abdominal radiography is often used, but its diagnostic utility requires evaluation.

Purpose of the Study:

  • To determine the prevalence and risk factors of constipation in pediatric CF patients.
  • To assess the effectiveness of abdominal radiography in diagnosing constipation in CF.
  • To identify key factors associated with constipation in this population.

Main Methods:

  • A cohort of 214 pediatric CF patients was studied.
  • Abdominal radiographs from 106 CF patients were assessed using Barr and Leech scores by multiple observers.
  • Statistical analysis identified independent risk factors for constipation.

Main Results:

  • Constipation prevalence was 47% in the studied CF cohort.
  • Low total fat absorption and a history of meconium ileus were significant independent risk factors.
  • Inter- and intraobserver variability for radiography scoring was poor to moderate, indicating limited reliability.

Conclusions:

  • Constipation is a significant issue in Cystic Fibrosis, strongly associated with impaired fat absorption and meconium ileus.
  • Abdominal radiography demonstrates limited value for the routine follow-up of CF patients regarding constipation.
  • Further research into optimal constipation management strategies in CF is warranted.
Abstract

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