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Related Experiment Video

Updated: Jun 17, 2026

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Chronic cough in upper airway diseases.

J B Watelet¹, T Van Zele, G Brusselle

¹Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium. jeanbaptiste.watelet@ugent.be

Respiratory Medicine

|December 17, 2009

Summary

Chronic cough is a significant indicator of asthma in patients with allergic rhinitis or chronic rhinosinusitis with nasal polyps. However, cough in chronic rhinosinusitis without polyps does not predict asthma, suggesting distinct underlying mechanisms.

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Area of Science:

Respiratory Medicine
Otolaryngology
Allergy Immunology

Background:

Established links exist between upper and lower airway diseases, with high comorbidity rates between asthma, rhinitis, and chronic rhinosinusitis (CRS).
Chronic cough is a common symptom in patients with coexisting upper and lower airway conditions.

Purpose of the Study:

To investigate the predictive value of chronic cough for the presence of concomitant asthma in patients with upper airway diseases.

Main Methods:

A cross-sectional study of 143 consecutive patients with simultaneous upper and lower airway disorders.
Patients were evaluated by ENT specialists and respiratory physicians, collecting demographic data and information on airway conditions.

Main Results:

Chronic cough was the primary complaint in the study population.
Patients with chronic cough showed a significantly increased risk of asthma when they also had allergic rhinitis (OR=5.8) or CRS with nasal polyps (OR=10.4).
Chronic cough did not predict asthma in patients with CRS without nasal polyps.

Conclusions:

Chronic cough serves as a key symptom for identifying associated asthma in allergic rhinitis and CRS with nasal polyps.
The lack of predictive value of cough in CRS without polyps suggests different pathophysiological pathways compared to other conditions.