Related Experiment Video
Updated: Jun 17, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Sclerosing mesenteritis: can it be a IgG4 dysimmune disease?]
Hicham Belghiti1, Dominique Cazals-Hatem, Anne Couvelard
1Service d'anatomie-pathologique, hôpital Beaujon, AP-HP, 92118 Clichy cedex, France.
Annales De Pathologie
|December 17, 2009
Summary
Inflammatory mesenteric diseases show heterogeneous histological features, with significant plasma cell, eosinophil, and TCD8+ lymphocyte components. These findings suggest a dysimmune pathogenesis distinct from hyper-IgG4 diseases.
Area of Science:
- Gastroenterology
- Pathology
- Immunology
Background:
- Mesenteric panniculitis (MP), sclerotic mesenteritis (SM), and mesenteric lipodystrophy (ML) are rare inflammatory mesenteric diseases with unknown pathogenesis.
- A dysimmune disorder is hypothesized as the underlying cause.
Purpose of the Study:
- To investigate the histological basis for a dysimmune disorder in inflammatory mesenteric diseases.
- To analyze the cellular components and immunohistochemical markers in MP, SM, and ML.
Main Methods:
- Histological analysis and systematic immunostaining (IgG4, CD3, CD8) were performed on patient samples.
- Dysimmune features were defined by specific thresholds for plasma cells, eosinophils, TCD8/CD3 ratio, and IgG4+ plasma cells.
- Cases were classified into MP, SM, or ML based on predominant histological components.
Main Results:
- Thirteen patients with inflammatory mesenteric disease were analyzed; paraffin blocks were available for ten.
- Histological analysis revealed plasma cell and eosinophil components in 46% and 23% of cases, respectively.
- Immunohistochemistry showed numerous TCD8+ cells in 80% of cases, but numerous IgG4+ plasma cells in only 31%.
Conclusions:
- Inflammatory mesenteric diseases exhibit significant heterogeneity in plasma cell, eosinophil, and TCD8+ lymphocyte infiltration.
- Eosinophils were predominantly observed in sclerotic mesenteric disease forms.
- The limited presence of IgG4+ plasma cells suggests a pathogenesis distinct from typical hyper-IgG4 related disorders.
Related Concept Videos
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:26Inflammatory Bowel Disease I: Introduction
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...